RLS3: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

K. M. Liebetanz; J. Winkelmann; C. Trenkwalder; B. Pütz; M. Dichgans; T. Gasser; B. Müller-Myhsok

doi:10.1212/01.wnl.0000224886.65213.b5

RLS3: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

K. M. Liebetanz, J. Winkelmann, C. Trenkwalder, B. Pütz, M. Dichgans, T. Gasser, B. Müller-Myhsok

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38 Scopus citations

Abstract

A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

Original language	English
Pages (from-to)	320-321
Number of pages	2
Journal	Neurology
Volume	67
Issue number	2
DOIs	https://doi.org/10.1212/01.wnl.0000224886.65213.b5
State	Published - Jul 2006
Externally published	Yes

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title = "RLS3: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity",

abstract = "A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).",

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T2 - Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

AU - Liebetanz, K. M.

AU - Winkelmann, J.

AU - Trenkwalder, C.

AU - Pütz, B.

AU - Dichgans, M.

AU - Gasser, T.

AU - Müller-Myhsok, B.

PY - 2006/7

Y1 - 2006/7

N2 - A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

AB - A new locus for restless legs syndrome (RLS3) was identified on chromosome 9p24-22. The authors analyzed transmission disequilibrium tests (TDTs) and affecteds-only linkage analysis in one large family of Bavarian origin, taking into account age at onset. P values were 0.0054 for marker D9S1810 for TDT and 0.0009 for the affecteds-only linkage analysis, providing a confirmation of RLS3. This study narrows the region containing the autosomal dominant RLS3 locus to 11.1 cM (16.6 Mbp).

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SN - 0028-3878

VL - 67

SP - 320

EP - 321

JO - Neurology

JF - Neurology

IS - 2

ER -

RLS3: Fine-mapping of an autosomal dominant locus in a family with intrafamilial heterogeneity

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