Risk factors for capillary leakage syndrome after bone marrow transplantation

W. Nürnberger, R. Willers, S. Burdach, U. Göbel

Research output: Contribution to journalArticlepeer-review

67 Scopus citations

Abstract

Age, hematopoietic growth factors, cyclosporin A, mode of bone marrow transplantation (BMT) (autologous, allogeneic-related, unrelated), and underlying disease were assessed as potential risk factors for capillary leakage syndrome (CLS) in 96 patients after BMT. CLS was defined as unexplained weight gain of > 3% within 24 h and nonresponsiveness to furosemide. CLS occurred in 9/21 patients after unrelated compared with 2/33 after allogeneic-related BMT (p = 0.0017) for hematopoietic disorders (n = 54) and in 6/7 patients after allogeneic-related compared with 3/35 after autologous BMT (p = 0.0001) for solid tumors (n = 42). Hematopoietic growth factors and cyclosporin A were no significant risk factors on their own. We conclude that unrelated BMTs or high-intensity conditioning regimens used in combination with allogeneic-related BMT are the main risk factors for CLS.

Original languageEnglish
Pages (from-to)221-224
Number of pages4
JournalAnnals of Hematology
Volume74
Issue number5
DOIs
StatePublished - May 1997
Externally publishedYes

Keywords

  • Capillary leakage syndrome
  • Cytokines
  • Endothelial damage
  • Pediatric solid tumors
  • Unrelated BMT

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