Rigid DNA beams for high-resolution single-molecule mechanics

Emanuel Pfitzner; Christian Wachauf; Fabian Kilchherr; Benjamin Pelz; William M. Shih; Matthias Rief; Hendrik Dietz

doi:10.1002/anie.201302727

Rigid DNA beams for high-resolution single-molecule mechanics

Emanuel Pfitzner, Christian Wachauf, Fabian Kilchherr, Benjamin Pelz, William M. Shih, Matthias Rief, Hendrik Dietz

Research output: Contribution to journal › Article › peer-review

100 Scopus citations

Abstract

Bridging the gap: Rigid DNA linkers (blue, see picture) between microspheres (green) for high-resolution single-molecule mechanical experiments were constructed using DNA origami. The resulting DNA helical bundles greatly reduce the noise generated in studies of conformation changes using optical tweezers and were applied to study small DNA secondary structures.

Original language	English
Pages (from-to)	7766-7771
Number of pages	6
Journal	Angewandte Chemie International Edition in English
Volume	52
Issue number	30
DOIs	https://doi.org/10.1002/anie.201302727
State	Published - 22 Jul 2013

Keywords

DNA nanotechnology
DNA structures
biophysics
force spectroscopy
single-molecule experiments

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10.1002/anie.201302727

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abstract = "Bridging the gap: Rigid DNA linkers (blue, see picture) between microspheres (green) for high-resolution single-molecule mechanical experiments were constructed using DNA origami. The resulting DNA helical bundles greatly reduce the noise generated in studies of conformation changes using optical tweezers and were applied to study small DNA secondary structures.",

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AU - Pfitzner, Emanuel

AU - Wachauf, Christian

AU - Kilchherr, Fabian

AU - Pelz, Benjamin

AU - Shih, William M.

AU - Rief, Matthias

AU - Dietz, Hendrik

PY - 2013/7/22

Y1 - 2013/7/22

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KW - DNA nanotechnology

KW - DNA structures

KW - biophysics

KW - force spectroscopy

KW - single-molecule experiments

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ER -

Rigid DNA beams for high-resolution single-molecule mechanics

Abstract

Keywords

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