Revolution in der Diabetesdiagnostik dank -omics - Biomarker mittels Metabolomics

Kilian Wörmann; Alesia Walker; Franco Moritz; Sara Forcisi; Dimitrios Tziotis; Marianna Lucio; Silke S. Heinzmann; Jerzy Adamski; Rainer Lehmann; Hans Ulrich Häring; Philippe Schmitt-Kopplin

doi:10.1055/s-0032-1320054

Revolution in der Diabetesdiagnostik dank -omics - Biomarker mittels Metabolomics

Translated title of the contribution: Revolution in diabetes diagnostics - Metabolomics for discovering biomarkers

Kilian Wörmann, Alesia Walker, Franco Moritz, Sara Forcisi, Dimitrios Tziotis, Marianna Lucio, Silke S. Heinzmann, Jerzy Adamski, Rainer Lehmann, Hans Ulrich Häring, Philippe Schmitt-Kopplin

Research output: Contribution to journal › Review article › peer-review

Abstract

In diabetes research Metabolomics is a new approach for discovering unknown diagnostic biomarkers for early detection and monitoring of the disease. Also new insights into the pathogenetic evolution of the metabolic disorder and its late complications are interesting. Since metabolites are intermediates and end product of all metabolic pathways they offer a high chance to identify new biomarkers or metabolic patterns. For that purpose either the number of detected metabolites is maximized or few are quantified in diverse biological samples like body fluids, tissues and cell cultures. Besides a general introduction to metabolomic research also a short summary of current metabolomics analysis in diabetic research will be presented in this review.

Translated title of the contribution	Revolution in diabetes diagnostics - Metabolomics for discovering biomarkers
Original language	German
Pages (from-to)	129-133
Number of pages	5
Journal	Diabetes Aktuell
Volume	10
Issue number	3
DOIs	https://doi.org/10.1055/s-0032-1320054
State	Published - 2012
Externally published	Yes

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10.1055/s-0032-1320054

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title = "Revolution in der Diabetesdiagnostik dank -omics - Biomarker mittels Metabolomics",

abstract = "In diabetes research Metabolomics is a new approach for discovering unknown diagnostic biomarkers for early detection and monitoring of the disease. Also new insights into the pathogenetic evolution of the metabolic disorder and its late complications are interesting. Since metabolites are intermediates and end product of all metabolic pathways they offer a high chance to identify new biomarkers or metabolic patterns. For that purpose either the number of detected metabolites is maximized or few are quantified in diverse biological samples like body fluids, tissues and cell cultures. Besides a general introduction to metabolomic research also a short summary of current metabolomics analysis in diabetic research will be presented in this review.",

keywords = "diabetes diagnostic, metabolic profiling, metabolite, metabonomics",

author = "Kilian W{\"o}rmann and Alesia Walker and Franco Moritz and Sara Forcisi and Dimitrios Tziotis and Marianna Lucio and Heinzmann, {Silke S.} and Jerzy Adamski and Rainer Lehmann and H{\"a}ring, {Hans Ulrich} and Philippe Schmitt-Kopplin",

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doi = "10.1055/s-0032-1320054",

language = "Deutsch",

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T1 - Revolution in der Diabetesdiagnostik dank -omics - Biomarker mittels Metabolomics

AU - Wörmann, Kilian

AU - Walker, Alesia

AU - Moritz, Franco

AU - Forcisi, Sara

AU - Tziotis, Dimitrios

AU - Lucio, Marianna

AU - Heinzmann, Silke S.

AU - Adamski, Jerzy

AU - Lehmann, Rainer

AU - Häring, Hans Ulrich

AU - Schmitt-Kopplin, Philippe

PY - 2012

Y1 - 2012

N2 - In diabetes research Metabolomics is a new approach for discovering unknown diagnostic biomarkers for early detection and monitoring of the disease. Also new insights into the pathogenetic evolution of the metabolic disorder and its late complications are interesting. Since metabolites are intermediates and end product of all metabolic pathways they offer a high chance to identify new biomarkers or metabolic patterns. For that purpose either the number of detected metabolites is maximized or few are quantified in diverse biological samples like body fluids, tissues and cell cultures. Besides a general introduction to metabolomic research also a short summary of current metabolomics analysis in diabetic research will be presented in this review.

AB - In diabetes research Metabolomics is a new approach for discovering unknown diagnostic biomarkers for early detection and monitoring of the disease. Also new insights into the pathogenetic evolution of the metabolic disorder and its late complications are interesting. Since metabolites are intermediates and end product of all metabolic pathways they offer a high chance to identify new biomarkers or metabolic patterns. For that purpose either the number of detected metabolites is maximized or few are quantified in diverse biological samples like body fluids, tissues and cell cultures. Besides a general introduction to metabolomic research also a short summary of current metabolomics analysis in diabetic research will be presented in this review.

KW - diabetes diagnostic

KW - metabolic profiling

KW - metabolite

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M3 - Übersichtsartikel

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SN - 1861-6089

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EP - 133

JO - Diabetes Aktuell

JF - Diabetes Aktuell

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ER -

Revolution in der Diabetesdiagnostik dank -omics - Biomarker mittels Metabolomics

Abstract

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