Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety

D. Brugger; B. Wagner; W. M. Windisch; H. Schenkel; K. Schulz; K. H. Südekum; A. Berk; R. Pieper; J. Kowalczyk; M. Spolders

doi:10.1016/j.animal.2022.100598

Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety

D. Brugger
, B. Wagner
, W. M. Windisch
, H. Schenkel
, K. Schulz
, K. H. Südekum
, A. Berk
, R. Pieper
, J. Kowalczyk
, M. Spolders

Chair of Animal Nutrition

University of Zurich
German Federal Institute for Risk Assessment (BfR)
Hohenheim University
Rheinische Friedrich-Wilhelms-Universität Bonn
Friedrich-Loeffler Institute

Research output: Contribution to journal › Review article › peer-review

25 Scopus citations

Abstract

Currently, the authorisation procedure of trace elements as feed additives in the European Union according to Regulation (EC) No. 1831/2003 does not consider the bioavailability of trace element sources. This manuscript provides framework conditions for in vivo experiments that aim to estimate differences in the relative bioavailability between supplements of essential trace elements. Framework conditions encompass necessary technical information on the test substance, the experimental design and diet composition as well as the suitability of status parameters that allow for relative comparisons of regression variables. This manuscript evolves recommendations for researchers to conduct solid and reliable experiments on the matter as well as decision makers to interpret the value of studies submitted with authorisation applications regarding a certain trace element supplement.

Original language	English
Article number	100598
Journal	Animal
Volume	16
Issue number	8
DOIs	https://doi.org/10.1016/j.animal.2022.100598
State	Published - Aug 2022

Keywords

Bioavailability
Experimental design
Livestock
Status parameters
Trace minerals

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10.1016/j.animal.2022.100598

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title = "Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety",

abstract = "Currently, the authorisation procedure of trace elements as feed additives in the European Union according to Regulation (EC) No. 1831/2003 does not consider the bioavailability of trace element sources. This manuscript provides framework conditions for in vivo experiments that aim to estimate differences in the relative bioavailability between supplements of essential trace elements. Framework conditions encompass necessary technical information on the test substance, the experimental design and diet composition as well as the suitability of status parameters that allow for relative comparisons of regression variables. This manuscript evolves recommendations for researchers to conduct solid and reliable experiments on the matter as well as decision makers to interpret the value of studies submitted with authorisation applications regarding a certain trace element supplement.",

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AU - Wagner, B.

AU - Windisch, W. M.

AU - Schenkel, H.

AU - Schulz, K.

AU - Südekum, K. H.

AU - Berk, A.

AU - Pieper, R.

AU - Kowalczyk, J.

AU - Spolders, M.

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AB - Currently, the authorisation procedure of trace elements as feed additives in the European Union according to Regulation (EC) No. 1831/2003 does not consider the bioavailability of trace element sources. This manuscript provides framework conditions for in vivo experiments that aim to estimate differences in the relative bioavailability between supplements of essential trace elements. Framework conditions encompass necessary technical information on the test substance, the experimental design and diet composition as well as the suitability of status parameters that allow for relative comparisons of regression variables. This manuscript evolves recommendations for researchers to conduct solid and reliable experiments on the matter as well as decision makers to interpret the value of studies submitted with authorisation applications regarding a certain trace element supplement.

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KW - Status parameters

KW - Trace minerals

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Review: Bioavailability of trace elements in farm animals: definition and practical considerations for improved assessment of efficacy and safety

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Keywords

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