TY - JOUR
T1 - Reversion-inducing cysteine-rich protein with Kazal motif (RECK) expression
T2 - An independent prognostic marker of survival in colorectal cancer
AU - Stenzinger, Albrecht
AU - Von Winterfeld, Moritz
AU - Rabien, Anja
AU - Warth, Arne
AU - Kamphues, Carsten
AU - Dietel, Manfred
AU - Weichert, Wilko
AU - Klauschen, Frederick
AU - Wittschieber, Daniel
N1 - Funding Information:
This work was supported by a Postdoctoral Research Fellowship of the Medical Faculty Heidelberg to A.S. We are grateful to Siegrun Blauhut for excellent technical assistance.
PY - 2012/8
Y1 - 2012/8
N2 - Patient prognosis in colorectal cancer is determined as in most solid cancers by the extent of local invasion and the presence of lymph node and distant metastases. The invasive potential of a tumor depends on the ability to degrade extracellular matrix proteins, for example, by matrix metalloproteinases. An important inhibitor of matrix metalloproteinases is reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein. This study investigated the prognostic relevance of RECK expression in colorectal cancer in a cohort of 283 patients. Analysis of immunohistochemical tissue microarray data showed that RECK protein levels did not seem to correlate with clinicopathologic parameters (Spearman rank correlation coefficients between -0.14 and -0.18) and that decreased RECK expression was an independent prognostic factor of poor survival, with a mean survival of 70 months in RECK-negative (146 cases) versus 97 months in RECK-positive patients (137 cases) (log-rank test, P =.002).
AB - Patient prognosis in colorectal cancer is determined as in most solid cancers by the extent of local invasion and the presence of lymph node and distant metastases. The invasive potential of a tumor depends on the ability to degrade extracellular matrix proteins, for example, by matrix metalloproteinases. An important inhibitor of matrix metalloproteinases is reversion-inducing cysteine-rich protein with Kazal motifs (RECK), a membrane-anchored glycoprotein. This study investigated the prognostic relevance of RECK expression in colorectal cancer in a cohort of 283 patients. Analysis of immunohistochemical tissue microarray data showed that RECK protein levels did not seem to correlate with clinicopathologic parameters (Spearman rank correlation coefficients between -0.14 and -0.18) and that decreased RECK expression was an independent prognostic factor of poor survival, with a mean survival of 70 months in RECK-negative (146 cases) versus 97 months in RECK-positive patients (137 cases) (log-rank test, P =.002).
KW - Colorectal cancer
KW - Matrix metalloproteinase
KW - RECK
UR - http://www.scopus.com/inward/record.url?scp=84863984419&partnerID=8YFLogxK
U2 - 10.1016/j.humpath.2011.10.012
DO - 10.1016/j.humpath.2011.10.012
M3 - Article
C2 - 22397871
AN - SCOPUS:84863984419
SN - 0046-8177
VL - 43
SP - 1314
EP - 1321
JO - Human Pathology
JF - Human Pathology
IS - 8
ER -
