Reversal of renal hypertension: Effects on renin, salt and water balance

R. Dietz, G. J. Mast, A. Schömig, J. B. Lüth, W. Rascher

Research output: Contribution to journalArticlepeer-review

6 Scopus citations


The effect of removal of one renal artery stenosis on renal sodium and fluid excretion and on the activity of the renin-angiotensin system (RAS) has been investigated in three types of renal hypertension of rats. Blood pressure fell in all experimental models after declamping, independently of changes in urinary sodium and water excretion or plasma angiotensin II (ANG II). Plasma concentrations of ANG II did not rise in response to salt and fluid loss induced by declamping when the contralateral kidney had been removed or when it was depleted from renin. A high renin content of the declamped kidney prevented major salt and fluid loss, whereas renin depletion of this kidney was accompanied by an exaggerated natriuresis and diuresis. Besides this tubular modulation of renal salt and water handling by the local RAS, glomerular filtration rate could be reduced by a stimulated activity of this system in plasma, indicated by a close relationship between serum urea and plasma ANG II levels.

Original languageEnglish
Pages (from-to)23-29
Number of pages7
JournalKlinische Wochenschrift
Issue number1 Supplement
StatePublished - Jan 1978
Externally publishedYes


  • Removal of one artery stenosis
  • Renal hypertension
  • Renin-angiotensin system
  • Salt and fluid loss


Dive into the research topics of 'Reversal of renal hypertension: Effects on renin, salt and water balance'. Together they form a unique fingerprint.

Cite this