Reusable Nickel Nanoparticles-Catalyzed Reductive Amination for Selective Synthesis of Primary Amines

Kathiravan Murugesan, Matthias Beller, Rajenahally V. Jagadeesh

Research output: Contribution to journalArticlepeer-review

101 Scopus citations

Abstract

The preparation of nickel nanoparticles as efficient reductive amination catalysts by pyrolysis of in situ generated Ni-tartaric acid complex on silica is presented. The resulting stable and reusable Ni-nanocatalyst enables the synthesis of functionalized and structurally diverse primary benzylic, heterocyclic and aliphatic amines starting from inexpensive and readily available carbonyl compounds and ammonia in presence of molecular hydrogen. Applying this Ni-based amination protocol, -NH 2 moiety can be introduced in structurally complex compounds, for example, steroid derivatives and pharmaceuticals.

Original languageEnglish
Pages (from-to)5064-5068
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume58
Issue number15
DOIs
StatePublished - 1 Apr 2019
Externally publishedYes

Keywords

  • ammonia
  • carbonyl compounds
  • nickel nanoparticles
  • primary amines
  • reductive amination

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