Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Yuchen Xia; Julie Lucifora; Florian Reisinger; Mathias Heikenwalder; Ulrike Protzer

doi:10.1126/science.1254083

Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Yuchen Xia, Julie Lucifora, Florian Reisinger, Mathias Heikenwalder, Ulrike Protzer

Chair of Virology

Technical University of Munich

Research output: Contribution to journal › Comment/debate

20 Scopus citations

Abstract

Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.

Original language	English
Pages (from-to)	1237b
Journal	Science
Volume	344
Issue number	6189
DOIs	https://doi.org/10.1126/science.1254083
State	Published - 2014

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AU - Heikenwalder, Mathias

AU - Protzer, Ulrike

PY - 2014

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AB - Chisari et al. challenge our central conclusion that the hepatitis B virus (HBV) persistent form, the covalently closed circular DNA (cccDNA), is degraded in a noncytotoxic and specific fashion in the nucleus of infected hepatocytes. Specificity of the assays used, exclusion of cell division or death, and activity of APOBEC3 deaminases in the nucleus, however, were addressed in the paper.

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Response to comment on "specific and nonhepatotoxic degradation of nuclear hepatitis B virus cccDNA"

Abstract

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