@article{af62cf3bd3834868904e1086b0602e32,
title = "Resistance of visna viras to interferon",
abstract = "Visna is a slow infection of sheep caused by a retrovirus. The persistence of virus despite the immune response of the host is best explained by restricted genetic expression of the virus and consequently prolonged periods of residence inside cells. The purpose of this investigation was to determine whether the restriction in genetic expression of visna virus is mediated by interferon. Sheep interferon induced by polyriboinosinic-polyribocytidylic acid in fetal lambs inhibited the growth of herpes simplex virus, vesicular stomatitis virus, and vaccinia virus, but even highly concentrated interferon did not affect the replication of visna virus in sheep choroid plexus cells. The same results were obtained whether the effects of interferon were assessed in single or multiple cycles of growth and when interferon was added at later times in the growth cycle of the virus. This unusual resistance of visna virus to interferon suggests that restriction of viral expression by the host is probably not mediated in this way.",
author = "D. Carroll and P. Ventura and A. Haase and Rinaldo, {C. R.} and Overall, {J. C.} and Glasgow, {L. A.} and D. Carroll and P. Ventura and A. Haase and Rinaldo, {C. R.} and Overall, {J. C.} and Glasgow, {L. A.}",
note = "Funding Information: The ability of visna virus to escape elimination by immune factors of the host is analogous in one major respect to lysogeny in bacteria. Visna virus is a retrovirus [3] capable of transferring the genetic information in its RNA genome to a stable DNA intermediate or provirus in the infected cell [4, 5]. In the infected animal, later stages in the life cycle of the virus are blocked, and this restriction in the expression of viral genetic information preserves a contingent of la- Received for publication January 23, 1978, and in revised form May 15, 1978. This work was supported by grants no. VC120C from the American Cancer Society and NS1l782, NSI2127·03, CA 09043-03, and Al 10217 from the U.S. Public Health Service and is project no. MRIS 3367 within the Veterans Administration. Dr. J. C. Overall, Jr. is an investigator of the Howard Hughes Medical Institute. Please address requests for reprints to Dr. D. Carroll, University of California Service, Veterans Administration Hospital, 151F, Building 1,Room no,4150 Clement Street, SanFrancisco, California 94121.",
year = "1978",
month = nov,
doi = "10.1093/infdis/138.5.614",
language = "English",
volume = "138",
pages = "614--617",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "5",
}
