Reprogramming tendon healing: a guide to novel molecular tools

Carlos Julio Peniche Silva, Elizabeth R. Balmayor, Martijn van Griensven

Research output: Contribution to journalReview articlepeer-review

Abstract

Tendons are a frequent site of injury, which greatly impairs the movement and locomotion of patients. Regrettably, injuries at the tendon frequently require surgical intervention, which leads to a long path to recovery. Moreover, the healing of tendons often involves the formation of scar tissue at the site of injury with poor mechanical properties and prone to re-injury. Tissue engineering carries the promise of better and more effective solutions to the improper healing of tendons. Lately, the field of regenerative medicine has seen a significant increase in the focus on the potential use of non-coding RNAs (e.g., siRNAs, miRNAs, and lncRNAs) as molecular tools for tendon tissue engineering. This class of molecules is being investigated due to their ability to act as epigenetic regulators of gene expression and protein production. Thus, providing a molecular instrument to fine-tune, reprogram, and modulate the processes of tendon differentiation, healing, and regeneration. This review focuses particularly on the latest advances involving the use of siRNAs, miRNAs, and lncRNAs in tendon tissue engineering applications.

Original languageEnglish
Article number1379773
JournalFrontiers in Bioengineering and Biotechnology
Volume12
DOIs
StatePublished - 2024
Externally publishedYes

Keywords

  • RNAi
  • lncRNA
  • mRNA silencing
  • miRNA
  • siRNA
  • tendon

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