Report of a metaplastic carcinoma of the breast with multi-directional differentiation: An adenoid cystic carcinoma, a spindle cell carcinoma and melanoma

Aurelia Noske; Michael Schwabe; Stefan Pahl; Eva Fallenberg; Christiane Richter-Ehrenstein; Manfred Dietel; Glen Kristiansen

doi:10.1007/s00428-008-0588-7

Report of a metaplastic carcinoma of the breast with multi-directional differentiation: An adenoid cystic carcinoma, a spindle cell carcinoma and melanoma

Aurelia Noske, Michael Schwabe, Stefan Pahl, Eva Fallenberg, Christiane Richter-Ehrenstein, Manfred Dietel, Glen Kristiansen

Charité – Universitätsmedizin Berlin

Research output: Contribution to journal › Article › peer-review

27 Scopus citations

Abstract

Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.

Original language	English
Pages (from-to)	575-579
Number of pages	5
Journal	Virchows Archiv
Volume	452
Issue number	5
DOIs	https://doi.org/10.1007/s00428-008-0588-7
State	Published - May 2008
Externally published	Yes

Keywords

Adenoid cystic cancer
Breast
Melanocytic differentiation
Metaplastic cancer

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s00428-008-0588-7

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abstract = "Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.",

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AU - Noske, Aurelia

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AU - Fallenberg, Eva

AU - Richter-Ehrenstein, Christiane

AU - Dietel, Manfred

AU - Kristiansen, Glen

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N2 - Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.

AB - Metaplastic carcinoma of the breast is a heterogeneous neoplasia, generally composed of both epithelial and mesenchymal components. We report an unusual case of mammary metaplastic carcinoma in a 51-year-old female patient. Needle core biopsy from the tumour mass showed malignant epithelial and sarcomatous features. The resection specimen revealed a multi-directional tumour differentiation consisting predominantly of: firstly, a poorly differentiated basaloid epithelial cell type, consistent with an adenoid cystic carcinoma; secondly, areas of a spindle cell carcinoma; and, thirdly, areas with a melanocytic differentiation. This is the first report on a metaplastic carcinoma of the breast presenting as an admixture of an adenoid cystic carcinoma and melanoma.

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Report of a metaplastic carcinoma of the breast with multi-directional differentiation: An adenoid cystic carcinoma, a spindle cell carcinoma and melanoma

Abstract

Keywords

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