Release of bombesin-like immunoreactivity from the isolated perfused rat stomach

V. Schusdziarra, H. Bender, E. F. Pfeiffer

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35 Scopus citations

Abstract

In the present study the release of bombesin-like immunoreactivity (BLI), somatostatin and gastrin was determined from the isolated perfused rat stomach. Gastric inhibitory polypeptide (GIP, 2 × 10-9 M) had no effect on BLI while stimulating somatostatin and gastrin release. In these experiments the luminal pH of the stomach was kept at pH 7. Reduction of the luminal pH to 2 resulted in an inhibition of BLI secretion by GIP while gastrin release was abolished and somatostatin remained unaffected compared to luminal pH 7. Acetylcholine (10-6 and 2 × 10-6 M) elicited a dose-dependent stimulation of BLI secretion while gastrin was stimulated and somatostatin secretion suppressed independent of the administered dose. The present data demonstrate that release of bombesin-like immunoreactivity can be modulated by intestinal hormones and neurotransmitters and is integrated into the complex system of gastrointestinal neuroendocrine regulation.

Original languageEnglish
Pages (from-to)21-29
Number of pages9
JournalRegulatory Peptides
Volume7
Issue number1
DOIs
StatePublished - Sep 1983
Externally publishedYes

Keywords

  • GIP
  • acetylcholine
  • bombesin
  • gastrin
  • rat stomach
  • somatostatin

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