Relation of cerebral tissue oxygenation index to central venous oxygen saturation in children

Nicole Nagdyman, Thilo Fleck, Sven Barth, Hashim Abdul-Khaliq, Brigitte Stiller, Peter Ewert, Michael Huebler, Hermann Kuppe, Peter E. Lange

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Objective: To evaluate the relationship between the cerebral tissue oxygenation index measured by near-infrared spectroscopy and central venous oxygen saturation (SvO2) after corrective surgery of congenital heart defects in children. Design: Prospective observational clinical study. Setting: A tertiary neonatal and paediatric intensive care unit for paediatric cardiology. Patients: Neonates and children consecutively admitted to the paediatric cardiology intensive care unit after corrective surgery of non-cyanotic congenital heart defects. Measurements and results: Forty-three children were studied. Cerebral tissue oxygenation index, measured non-invasively by near-infrared spectroscopy, was compared to SvO2, measured by a catheter placed in the right atrium, and to haemodynamic and respiratory parameters. Pearson's correlation co-efficients and p values were calculated. Simultaneously measured values for SvO2 (62.2±9.8%, 39.8-80.4%) and cerebral tissue oxygenation index (56.7±8.8%, 35.8-71.2%) showed a significant correlation (r=0.52, p<0.001). Conclusion: Cerebral tissue oxygenation index and SvO2 are not interchangeable parameters, but cerebral tissue oxygenation index reflects the haemodynamic influence on cerebral oxygenation after cardiovascular surgery. Further work is necessary to confirm the clinical role of continuous non-invasive measurement of cerebral tissue oxygenation index with regard to the variations of global systemic oxygen consumption after cardiac surgery in children.

Original languageEnglish
Pages (from-to)468-471
Number of pages4
JournalIntensive Care Medicine
Issue number3
StatePublished - Mar 2004
Externally publishedYes


  • Central venous oxygen saturation
  • Cerebral oxygenation
  • Children
  • Congenital heart defects
  • Near-infrared spectroscopy
  • Tissue oxygenation index


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