Regulators of PP2C phosphatase activity function as abscisic acid sensors

Yue Ma; Izabela Szostkiewicz; Arthur Korte; Danièle Moes; Yi Yang; Alexander Christmann; Erwin Grill

doi:10.1126/science.1172408

Regulators of PP2C phosphatase activity function as abscisic acid sensors

Yue Ma, Izabela Szostkiewicz, Arthur Korte, Danièle Moes, Yi Yang, Alexander Christmann, Erwin Grill

Chair of Botany

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1958 Scopus citations

Abstract

The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2, which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.

Original language	English
Pages (from-to)	1064-1068
Number of pages	5
Journal	Science
Volume	324
Issue number	5930
DOIs	https://doi.org/10.1126/science.1172408
State	Published - 22 May 2009

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abstract = "The plant hormone abscisic acid (ABA) acts as a developmental signal and as an integrator of environmental cues such as drought and cold. Key players in ABA signal transduction include the type 2C protein phosphatases (PP2Cs) ABI1 and ABI2, which act by negatively regulating ABA responses. In this study, we identify interactors of ABI1 and ABI2, which we have named regulatory components of ABA receptor (RCARs). In Arabidopsis, RCARs belong to a family with 14 members that share structural similarity with class 10 pathogen-related proteins. RCAR1 was shown to bind ABA, to mediate ABA-dependent inactivation of ABI1 or ABI2 in vitro, and to antagonize PP2C action in planta. Other RCARs also mediated ABA-dependent regulation of ABI1 and ABI2, consistent with a combinatorial assembly of receptor complexes.",

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AU - Ma, Yue

AU - Szostkiewicz, Izabela

AU - Korte, Arthur

AU - Moes, Danièle

AU - Yang, Yi

AU - Christmann, Alexander

AU - Grill, Erwin

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Regulators of PP2C phosphatase activity function as abscisic acid sensors

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