Regulation of the germinal center response by MicroRNA-155

To Ha Thai; Dinis Pedro Calado; Stefano Casola; K. Mark Ansel; Changchun Xiao; Yingzi Xue; Andrew Murphy; David Frendewey; David Valenzuela; Jeffery L. Kutok; Marc Schmidt-Supprian; Nikolaus Rajewsky; George Yancopoulos; Anjana Rao; Klaus Rajewsky

doi:10.1126/science.1141229

Regulation of the germinal center response by MicroRNA-155

To Ha Thai, Dinis Pedro Calado, Stefano Casola, K. Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David Valenzuela, Jeffery L. Kutok, Marc Schmidt-Supprian, Nikolaus Rajewsky, George Yancopoulos, Anjana Rao, Klaus Rajewsky

Research output: Contribution to journal › Article › peer-review

1347 Scopus citations

Abstract

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

Original language	English
Pages (from-to)	604-608
Number of pages	5
Journal	Science
Volume	316
Issue number	5824
DOIs	https://doi.org/10.1126/science.1141229
State	Published - 27 Apr 2007
Externally published	Yes

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title = "Regulation of the germinal center response by MicroRNA-155",

abstract = "MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.",

author = "Thai, {To Ha} and Calado, {Dinis Pedro} and Stefano Casola and Ansel, {K. Mark} and Changchun Xiao and Yingzi Xue and Andrew Murphy and David Frendewey and David Valenzuela and Kutok, {Jeffery L.} and Marc Schmidt-Supprian and Nikolaus Rajewsky and George Yancopoulos and Anjana Rao and Klaus Rajewsky",

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T1 - Regulation of the germinal center response by MicroRNA-155

AU - Thai, To Ha

AU - Calado, Dinis Pedro

AU - Casola, Stefano

AU - Ansel, K. Mark

AU - Xiao, Changchun

AU - Xue, Yingzi

AU - Murphy, Andrew

AU - Frendewey, David

AU - Valenzuela, David

AU - Kutok, Jeffery L.

AU - Schmidt-Supprian, Marc

AU - Rajewsky, Nikolaus

AU - Yancopoulos, George

AU - Rao, Anjana

AU - Rajewsky, Klaus

PY - 2007/4/27

Y1 - 2007/4/27

N2 - MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

AB - MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

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SN - 0036-8075

VL - 316

SP - 604

EP - 608

JO - Science

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Regulation of the germinal center response by MicroRNA-155

Abstract

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