Regulation of proinflammatory cytokines by commensal and probiotic bacteria

J. C. Cender, D. Haller, L. Holt, B. Sartor

Research output: Contribution to journalArticlepeer-review

Abstract

Preincubation with nonviable VSL-3 lysate inhibits in vitro splenocyte TNF production stimulated by physiologic cecal bacterial products. VSL-3 lysate stimulates IL-10 production, but this inhibition of TNF secretion is IL-10 independent. A protein fraction of VSL-3 stimulates IL-10 secretion, but inhibitory activities of VSL-3 are not mediated by protein or DNA components.

Original languageEnglish
Pages (from-to)64-68
Number of pages5
JournalEOS Rivista di Immunologia ed Immunofarmacologia
Volume24
Issue number1-2
StatePublished - 2004
Externally publishedYes

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