Regulation of Na+/Ca2+ exchange current in the normal and failing heart

Michael Reppel; Bernd K. Fleischmann; Hannes Reuter; Frank Pillekamp; Heribert Schunkert; Jürgen Hescheler

doi:10.1196/annals.1387.065

Regulation of Na⁺/Ca²⁺ exchange current in the normal and failing heart

Michael Reppel, Bernd K. Fleischmann, Hannes Reuter, Frank Pillekamp, Heribert Schunkert, Jürgen Hescheler

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

12 Scopus citations

Abstract

Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na⁺ and Ca²⁺ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.

Original language	English
Title of host publication	Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion
Subtitle of host publication	Fifth International Conference
Publisher	Blackwell Publishing Inc.
Pages	361-372
Number of pages	12
ISBN (Print)	1573316490, 9781573316491
DOIs	https://doi.org/10.1196/annals.1387.065
State	Published - Mar 2007
Externally published	Yes

Publication series

Name	Annals of the New York Academy of Sciences
Volume	1099
ISSN (Print)	0077-8923
ISSN (Electronic)	1749-6632

Keywords

Calcium
Cardiac development
Electrophysiology
Embryonic heart
NCX

Access to Document

10.1196/annals.1387.065

Cite this

Reppel, M., Fleischmann, B. K., Reuter, H., Pillekamp, F., Schunkert, H., & Hescheler, J. (2007). Regulation of Na⁺/Ca²⁺ exchange current in the normal and failing heart. In Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference (pp. 361-372). (Annals of the New York Academy of Sciences; Vol. 1099). Blackwell Publishing Inc.. https://doi.org/10.1196/annals.1387.065

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title = "Regulation of Na+/Ca2+ exchange current in the normal and failing heart",

abstract = "Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na+ and Ca2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.",

keywords = "Calcium, Cardiac development, Electrophysiology, Embryonic heart, NCX",

author = "Michael Reppel and Fleischmann, {Bernd K.} and Hannes Reuter and Frank Pillekamp and Heribert Schunkert and J{\"u}rgen Hescheler",

year = "2007",

month = mar,

doi = "10.1196/annals.1387.065",

language = "English",

isbn = "1573316490",

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Reppel, M, Fleischmann, BK, Reuter, H, Pillekamp, F, Schunkert, H & Hescheler, J 2007, Regulation of Na⁺/Ca²⁺ exchange current in the normal and failing heart. in Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Annals of the New York Academy of Sciences, vol. 1099, Blackwell Publishing Inc., pp. 361-372. https://doi.org/10.1196/annals.1387.065

Regulation of Na⁺/Ca²⁺ exchange current in the normal and failing heart. / Reppel, Michael; Fleischmann, Bernd K.; Reuter, Hannes et al.
Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Blackwell Publishing Inc., 2007. p. 361-372 (Annals of the New York Academy of Sciences; Vol. 1099).

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution › peer-review

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Reppel M, Fleischmann BK, Reuter H, Pillekamp F, Schunkert H, Hescheler J. Regulation of Na⁺/Ca²⁺ exchange current in the normal and failing heart. In Sodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion: Fifth International Conference. Blackwell Publishing Inc. 2007. p. 361-372. (Annals of the New York Academy of Sciences). doi: 10.1196/annals.1387.065