Regulation of Na+/Ca2+ exchange current in the normal and failing heart

Michael Reppel, Bernd K. Fleischmann, Hannes Reuter, Frank Pillekamp, Heribert Schunkert, Jürgen Hescheler

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

12 Scopus citations


Cardiac NCX is modulated by diverse regulatory elements. Although there is consensus about the regulatory function of Na+ and Ca2+ and other elements, for example, ATP, there is still a controversial debate about the functional role of cyclic nucleotides and protein kinases. Future studies should focus on that topic since disturbances of cAMP/cGMP concentration and kinase activity may lead to severe functional disorders in the diseased heart. S100A1 is presumably a novel regulator of NCX.

Original languageEnglish
Title of host publicationSodium-Calcium Exchange and the Plasma Membrane Ca2+ATPase in Ce;; Funcyion
Subtitle of host publicationFifth International Conference
PublisherBlackwell Publishing Inc.
Number of pages12
ISBN (Print)1573316490, 9781573316491
StatePublished - Mar 2007
Externally publishedYes

Publication series

NameAnnals of the New York Academy of Sciences
ISSN (Print)0077-8923
ISSN (Electronic)1749-6632


  • Calcium
  • Cardiac development
  • Electrophysiology
  • Embryonic heart
  • NCX


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