TY - JOUR
T1 - Regulation of endothelial progenitor cell functions during hyperglycemia
T2 - new therapeutic targets in diabetic wound healing
AU - Wan, Gui
AU - Chen, Yangyang
AU - Chen, Jing
AU - Yan, Chengqi
AU - Wang, Cheng
AU - Li, Wenqing
AU - Mao, Renqun
AU - Machens, Hans Günther
AU - Yang, Xiaofan
AU - Chen, Zhenbing
N1 - Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
PY - 2022/4
Y1 - 2022/4
N2 - Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precursors of endothelial cells (ECs), these cells were discovered in 1997 and found to play an essential role in wound healing. Their function, number, and role in wound healing has been widely investigated. Hitherto, a lot of complex molecular mechanisms have been discovered. In this review, we summarize the mechanisms of how hyperglycemia affects the function and number of EPCs and how the affected cells impact wound healing. We aim to provide a complete summary of the relationship between diabetic hyperglycosemia, EPCs, and wound healing, as well as a better comprehensive platform for subsequent related research.
AB - Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precursors of endothelial cells (ECs), these cells were discovered in 1997 and found to play an essential role in wound healing. Their function, number, and role in wound healing has been widely investigated. Hitherto, a lot of complex molecular mechanisms have been discovered. In this review, we summarize the mechanisms of how hyperglycemia affects the function and number of EPCs and how the affected cells impact wound healing. We aim to provide a complete summary of the relationship between diabetic hyperglycosemia, EPCs, and wound healing, as well as a better comprehensive platform for subsequent related research.
KW - Diabetes
KW - EPCs
KW - Hyperglycemia
KW - Wound healing
UR - http://www.scopus.com/inward/record.url?scp=85122596122&partnerID=8YFLogxK
U2 - 10.1007/s00109-021-02172-1
DO - 10.1007/s00109-021-02172-1
M3 - Review article
C2 - 34997250
AN - SCOPUS:85122596122
SN - 0946-2716
VL - 100
SP - 485
EP - 498
JO - Journal of Molecular Medicine
JF - Journal of Molecular Medicine
IS - 4
ER -
