Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Carsten B. Schmidt-Weber; Kurt Blaser

doi:10.1016/j.coi.2004.09.008

Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Carsten B. Schmidt-Weber
, Kurt Blaser

Schweizerisches Institut für Allergie- und Asthmaforschung (SIAF), Swiss Institute for Allergy and Asthma Research

Research output: Contribution to journal › Review article › peer-review

116 Scopus citations

Abstract

Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

Original language	English
Pages (from-to)	709-716
Number of pages	8
Journal	Current Opinion in Immunology
Volume	16
Issue number	6
DOIs	https://doi.org/10.1016/j.coi.2004.09.008
State	Published - Dec 2004
Externally published	Yes

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title = "Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation",

abstract = "Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.",

author = "Schmidt-Weber, \{Carsten B.\} and Kurt Blaser",

note = "Funding Information: This work was supported by grants from the Swiss National Foundation (31-65436.01, 32-100266 and 3100A0-100164), by the Ehmann Foundation, the Saurer Foundation, the Jubil{\"a}umsstiftung der Schweizerischen Lebensversicherungs-und Rentenanstalt f{\"u}r Volksgesundheit und medizinische Forschung and the Ernst-G{\"o}hner Stiftung, Zug.",

year = "2004",

month = dec,

doi = "10.1016/j.coi.2004.09.008",

language = "English",

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journal = "Current Opinion in Immunology",

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T1 - Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

AU - Schmidt-Weber, Carsten B.

AU - Blaser, Kurt

N1 - Funding Information: This work was supported by grants from the Swiss National Foundation (31-65436.01, 32-100266 and 3100A0-100164), by the Ehmann Foundation, the Saurer Foundation, the Jubiläumsstiftung der Schweizerischen Lebensversicherungs-und Rentenanstalt für Volksgesundheit und medizinische Forschung and the Ernst-Göhner Stiftung, Zug.

PY - 2004/12

Y1 - 2004/12

N2 - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

AB - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.

UR - https://www.scopus.com/pages/publications/7044284788

U2 - 10.1016/j.coi.2004.09.008

DO - 10.1016/j.coi.2004.09.008

M3 - Review article

C2 - 15511662

AN - SCOPUS:7044284788

SN - 0952-7915

VL - 16

SP - 709

EP - 716

JO - Current Opinion in Immunology

JF - Current Opinion in Immunology

IS - 6

ER -

Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation

Abstract

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