TY - JOUR
T1 - Regulation and role of transforming growth factor-β in immune tolerance induction and inflammation
AU - Schmidt-Weber, Carsten B.
AU - Blaser, Kurt
N1 - Funding Information:
This work was supported by grants from the Swiss National Foundation (31-65436.01, 32-100266 and 3100A0-100164), by the Ehmann Foundation, the Saurer Foundation, the Jubiläumsstiftung der Schweizerischen Lebensversicherungs-und Rentenanstalt für Volksgesundheit und medizinische Forschung and the Ernst-Göhner Stiftung, Zug.
PY - 2004/12
Y1 - 2004/12
N2 - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.
AB - Transforming growth factor-β (TGF-β) is known to mediate pleiotropic functions both inside and outside the immune system. Recent progress in this field underlines the role of TGF-β in regulatory T (Treg) cells, where it participates in both suppression and differentiation. In addition, recent information highlights the role of TGF-β in repair responses that lead to matrix deposition and tissue remodelling. Many chronic inflammatory diseases, such as asthma, profit from the suppression of specific immune responses by TGF-β; however, TGF-β-mediated tissue remodelling can be a serious complication in such diseases.
UR - http://www.scopus.com/inward/record.url?scp=7044284788&partnerID=8YFLogxK
U2 - 10.1016/j.coi.2004.09.008
DO - 10.1016/j.coi.2004.09.008
M3 - Review article
C2 - 15511662
AN - SCOPUS:7044284788
SN - 0952-7915
VL - 16
SP - 709
EP - 716
JO - Current Opinion in Immunology
JF - Current Opinion in Immunology
IS - 6
ER -