Registration of 3-D CT and 2-D flat images of mouse via affine transformation

Zheng Xia, Xishi Huang, Xiaobo Zhou, Youxian Sun, Vasilis Ntziachristos, Stephen T.C. Wong

Research output: Contribution to journalArticlepeer-review

20 Scopus citations


It is difficult to directly coregister the 3-D fluorescence molecular tomography (FMT) image of a small tumor in a mouse whose maximal diameter is only a few millimeters with a larger CT image of the entire animal that spans about 10 cm. This paper proposes a new method to register 2-D flat and 3-D CT image first to facilitate the registration between small 3-D FMT images and large 3-D CT images. A novel algorithm combining differential evolution and improved simplex method for the registration between the 2-D flat and 3-D CT images is introduced and validated with simulated images and real images of mice. The visualization of the alignment of the 3-D FMT and CT image through 2-D registration shows promising results.

Original languageEnglish
Pages (from-to)569-578
Number of pages10
JournalIEEE Transactions on Information Technology in Biomedicine
Issue number5
StatePublished - 2008
Externally publishedYes


  • Animal molecular imaging
  • Fluorescence molecular (FMT)
  • Registration
  • Snake model


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