Abstract
The 2,3,4-tribromopyrrole 4 and the 2,3-dibromopyrrole 10 were shown to undergo regioselective Suzuki cross-coupling reactions at the 2-position. After optimization best yields in the reaction with 4-tert-butylphenyl boronic acid (5a) were 68% and 86%. Other boronic acids 5 were employed in the reaction with pyrrole 4 and gave the monosubstitution products 6 in 33-52% yield. A subsequent cross-coupling at positions C-3 and C-4 could be achieved on 3,4-dibromopyrrole 6a (84% yield).
Original language | English |
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Pages (from-to) | 1957-1959 |
Number of pages | 3 |
Journal | Synlett |
Issue number | 12 |
DOIs | |
State | Published - 1 Aug 2005 |
Keywords
- Catalysis
- Cross-coupling
- Heterocycles
- Palladium
- Pyrroles
- Regioselectivity