Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles

Jola Pospech, Anis Tlili, Anke Spannenberg, Helfried Neumann, Matthias Beller

Research output: Contribution to journalArticlepeer-review

30 Scopus citations

Abstract

A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed. By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2)C(sp2) bond formation has been achieved. This straightforward catalytic process provides access to versatile products prevalent in multiple bioactive compounds and supplies a valuable functional group for subsequent transformations. C H bond functionalization: A ruthenium-catalyzed carbonylative CH bond arylation process for the three-component synthesis of complex aryl-(hetero)aryl ketones in an aqueous solution has been developed (see scheme). By exploiting the ortho-activating effect of nitrogen-containing directing groups, a regioselective, successive twofold C(sp2) C(sp2) bond formation has been achieved.

Original languageEnglish
Pages (from-to)3135-3141
Number of pages7
JournalChemistry - A European Journal
Volume20
Issue number11
DOIs
StatePublished - 10 Mar 2014
Externally publishedYes

Keywords

  • CH bond functionalization
  • carbonylative coupling
  • heterocycles
  • multicomponent reactions
  • ruthenium

Fingerprint

Dive into the research topics of 'Regioselective ruthenium-catalyzed carbonylative direct arylation of five-membered and condensed heterocycles'. Together they form a unique fingerprint.

Cite this