Regioselective Pd-Catalyzed Methoxycarbonylation of Alkenes Using both Paraformaldehyde and Methanol as CO Surrogates

Qiang Liu, Kedong Yuan, Percia Beatrice Arockiam, Robert Franke, Henri Doucet, Ralf Jackstell, Matthias Beller

Research output: Contribution to journalArticlepeer-review

68 Scopus citations

Abstract

In recent years, considerable effort has focused on the development of novel carbonylative transformations using CO surrogates. Consequently, toxic CO gas can be replaced by more convenient inorganic or organic carbonyl compounds. Herein, the first regioselective methoxycarbonylation of alkenes with paraformaldehyde and methanol as CO substitutes is reported. This new procedure is applicable to a series of alkenes in the presence of a palladium catalyst under relatively mild conditions and is highly atom efficient.

Original languageEnglish
Pages (from-to)4493-4497
Number of pages5
JournalAngewandte Chemie International Edition in English
Volume54
Issue number15
DOIs
StatePublished - 7 Apr 2015
Externally publishedYes

Keywords

  • CO surrogates
  • carbonylation
  • formaldehyde
  • methanol
  • palladium

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