Regional lung ventilation estimation based on supervoxel tracking

Adam Szmul, Bartlomiej W. Papiez, Tahreema Matin, Fergus V. Gleeson, Julia A. Schnabel, Vicente Grau

Research output: Chapter in Book/Report/Conference proceedingConference contributionpeer-review

2 Scopus citations

Abstract

In the case of lung cancer, an assessment of regional lung function has the potential to guide more accurate radiotherapy treatment. This could spare well-functioning parts of the lungs, as well as be used for follow up. In this paper we present a novel approach for regional lung ventilation estimation from dynamic lung CT imaging, which might be used during radiotherapy planning. Our method combines a supervoxel-based image representation with deformable image registration, performed between peak breathing phases, for which we track changes in intensity of previously extracted supervoxels. Such a region-oriented approach is expected to be more physiologically consistent with lung anatomy than previous methods relying on voxel-wise relationships, as it has the potential to mimic the lung anatomy. Our results are compared with static ventilation images acquired from hyperpolarized Xenon129 MRI. In our study we use three patient datasets consisting of 4DCT and XeMRI. We achieve higher correlation (0.487) compared to the commonly used method for estimating ventilation performed in a voxel-wise manner (0.423) on average based on global correlation coefficients. We also achieve higher correlation values for our method when ventilated/non-ventilated regions of lungs are investigated. The increase of the number of layers of supervoxels further improves our results, with one layer achieving 0.393, compared to 0.487 for 15 layers. Overall, we have shown that our method achieves higher correlation values compared to the previously used approach, when correlated with XeMRI.

Original languageEnglish
Title of host publicationMedical Imaging 2018
Subtitle of host publicationImage-Guided Procedures, Robotic Interventions, and Modeling
EditorsBaowei Fei, Robert J. Webster
PublisherSPIE
ISBN (Electronic)9781510616417
DOIs
StatePublished - 2018
Externally publishedYes
EventMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling - Houston, United States
Duration: 12 Feb 201815 Feb 2018

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10576
ISSN (Print)1605-7422

Conference

ConferenceMedical Imaging 2018: Image-Guided Procedures, Robotic Interventions, and Modeling
Country/TerritoryUnited States
CityHouston
Period12/02/1815/02/18

Keywords

  • Image registration
  • Lung ventilation estimation
  • Supervoxels
  • Tracking

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