Reflections on the construction of anion receptors. Is there a sign to resign from design?

Research output: Contribution to journalReview articlepeer-review

178 Scopus citations


The principles and conceptual basis of the design of molecular hosts for anions is examined. Starting from general considerations on the fundamentals of supramolecular binding and selectivity the role of the underlying model is illuminated. Turning to an agenda to be followed in the construction of concrete anion hosts the aspects of function, the guest to be bound, the competition situation and the strategic feasibility are discussed. Finally, arguments to include various facets of association entropy are presented that were unraveled by recent experimental studies. As a conclusion, the necessity to consider entropic influences in host design is emphasized. Although this adds to the complexity of the design task an optimistic prospect for success is voiced in view of recent progress in computational prediction and the support from experimental entropy data.

Original languageEnglish
Pages (from-to)2918-2928
Number of pages11
JournalCoordination Chemistry Reviews
Issue number23-24
StatePublished - Dec 2006


  • Anion receptor
  • Association entropy
  • Host-guest design
  • Molecular recognition
  • Selectivity


Dive into the research topics of 'Reflections on the construction of anion receptors. Is there a sign to resign from design?'. Together they form a unique fingerprint.

Cite this