Abstract
The way forward: In the last two decades a novel biosynthetic route to isopentenyl diphosphate and dimethylallyl diphosphate, the non-mevalonate or deoxyxylulose pathway, has been elucidated. The IspH protein (see space-filling model) catalyzes the terminal step of this biosynthetic pathway. The enzymes of this pathway are absent in mammals and are validated targets for new antibiotics.
| Original language | English |
|---|---|
| Pages (from-to) | 8802-8809 |
| Number of pages | 8 |
| Journal | Angewandte Chemie International Edition in English |
| Volume | 49 |
| Issue number | 47 |
| DOIs | |
| State | Published - 15 Nov 2010 |
Keywords
- IspH protein
- LytB protein
- deoxyxylulose phosphate pathway
- iron-sulfur clusters
- isoprenoid Weinheim.biosynthesis