Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome

Sebastian Stentzel; Beate Hagl; Felicitas Abel; Barbara C. Kahl; Anita Rack-Hoch; Barbara M. Bröker; Ellen D. Renner

doi:10.1093/cid/cix140

Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome

Sebastian Stentzel, Beate Hagl, Felicitas Abel, Barbara C. Kahl, Anita Rack-Hoch, Barbara M. Bröker, Ellen D. Renner

Assistant Professorship of Translational Immunology in Environmental Health

Research output: Contribution to journal › Article › peer-review

12 Scopus citations

Abstract

STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

Original language	English
Pages (from-to)	1279-1282
Number of pages	4
Journal	Clinical Infectious Diseases
Volume	64
Issue number	9
DOIs	https://doi.org/10.1093/cid/cix140
State	Published - 1 May 2017

Keywords

Adaptive immunity
Cystic fibrosis
HIES
Hyper-IgE Syndrome
S. aureus
STAT3
Specific IgG
Th17

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1093/cid/cix140

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title = "Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome",

abstract = "STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.",

keywords = "Adaptive immunity, Cystic fibrosis, HIES, Hyper-IgE Syndrome, S. aureus, STAT3, Specific IgG, Th17",

author = "Sebastian Stentzel and Beate Hagl and Felicitas Abel and Kahl, {Barbara C.} and Anita Rack-Hoch and Br{\"o}ker, {Barbara M.} and Renner, {Ellen D.}",

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language = "English",

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T1 - Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome

AU - Stentzel, Sebastian

AU - Hagl, Beate

AU - Abel, Felicitas

AU - Kahl, Barbara C.

AU - Rack-Hoch, Anita

AU - Bröker, Barbara M.

AU - Renner, Ellen D.

N1 - Publisher Copyright: © The Author 2017.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

AB - STAT3 hyper-IgE syndrome (STAT3-HIES) patients presented with significantly lower Staphylococcus aureus-specific serum IgG compared to cystic fibrosis patients despite recurrent S. aureus infections. Immunoglobulin replacement therapy increased S. aureus-specific IgG in STAT3-HIES patients and attenuated the clinical course of disease suggesting a role of humoral immunity in S. aureus clearance.

KW - Adaptive immunity

KW - Cystic fibrosis

KW - HIES

KW - Hyper-IgE Syndrome

KW - S. aureus

KW - STAT3

KW - Specific IgG

KW - Th17

UR - http://www.scopus.com/inward/record.url?scp=85020029512&partnerID=8YFLogxK

U2 - 10.1093/cid/cix140

DO - 10.1093/cid/cix140

M3 - Article

C2 - 28203787

AN - SCOPUS:85020029512

SN - 1058-4838

VL - 64

SP - 1279

EP - 1282

JO - Clinical Infectious Diseases

JF - Clinical Infectious Diseases

IS - 9

ER -

Reduced immunoglobulin (Ig) G response to Staphylococcus aureus in STAT3 hyper-IgE syndrome

Abstract

Keywords

UN SDGs

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