Redox imaging using genetically encoded redox indicators in zebrafish and mice

Michael O. Breckwoldt, Christine Wittmann, Thomas Misgeld, Martin Kerschensteiner, Clemens Grabher

Research output: Contribution to journalReview articlepeer-review

13 Scopus citations

Abstract

Redox signals have emerged as important regulators of cellular physiology and pathology. The advent of redox imaging in vertebrate systems now provides the opportunity to dynamically visualize redox signaling during development and disease. In this review, we summarize recent advances in the generation of genetically encoded redox indicators (GERIs), introduce new redox imaging strategies, and highlight key publications in the field of vertebrate redox imaging. We also discuss the limitations and future potential of in vivo redox imaging in zebrafish and mice.

Original languageEnglish
Pages (from-to)511-522
Number of pages12
JournalBiological Chemistry
Volume396
Issue number5
DOIs
StatePublished - 1 May 2015
Externally publishedYes

Keywords

  • Genetically encoded redox indicators
  • Grx1-roGFP2
  • HyPer
  • In vivo microscopy
  • Redox signals
  • roGFP

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