Redox cycling for passive modification of polypyrrole surface properties: Effects on cell adhesion and proliferation

Kartik M. Sivaraman, Berna Özkale, Olgaç Ergeneman, Tessa Lühmann, Giuseppino Fortunato, Muhammad Arif Zeeshan, Bradley J. Nelson, Salvador Pané

Research output: Contribution to journalArticlepeer-review

15 Scopus citations

Abstract

The surface properties of electrodeposited poly(pyrrole) (Ppy) doped with sodium dodecylbenzenesulphonate (NaDBS) are modified by two methods: addition of poly(ethylene glycol) (PEG) during the electrodeposition and through redox cycling post electrodeposition. X-ray photoelectron spectroscopy (XPS) was used to ascertain PEG incorporation and to analyze the change in the oxidation state of the polymer. Anodic cycling resulted in the formation of micrometer-sized surface cracks which increased the amount of Rhodamine-B dye adsorbed onto the surface, and played a role in decreasing the wettability of the surface. The change in surface wettability caused by these cracks was mitigated by the presence of PEG in the Ppy matrix. Compared to the incorporation of PEG, redox cycling was more effective in passively modulating the adhesion of NIH 3T3 fibroblast cells on the Ppy surface. Based on the attenuation of surface polarity of the Ppy surfaces by the incorporated PEG, a mechanism is proposed to explain the observed cell adhesion behavior.

Original languageEnglish
Pages (from-to)591-598
Number of pages8
JournalAdvanced Healthcare Materials
Volume2
Issue number4
DOIs
StatePublished - Apr 2013
Externally publishedYes

Keywords

  • Cell adhesion
  • Polyethylene glycol
  • Polypyrrole
  • Redox cycling
  • X-ray photoelectron spectroscopy

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