TY - JOUR
T1 - Redox cycling for passive modification of polypyrrole surface properties
T2 - Effects on cell adhesion and proliferation
AU - Sivaraman, Kartik M.
AU - Özkale, Berna
AU - Ergeneman, Olgaç
AU - Lühmann, Tessa
AU - Fortunato, Giuseppino
AU - Zeeshan, Muhammad Arif
AU - Nelson, Bradley J.
AU - Pané, Salvador
PY - 2013/4
Y1 - 2013/4
N2 - The surface properties of electrodeposited poly(pyrrole) (Ppy) doped with sodium dodecylbenzenesulphonate (NaDBS) are modified by two methods: addition of poly(ethylene glycol) (PEG) during the electrodeposition and through redox cycling post electrodeposition. X-ray photoelectron spectroscopy (XPS) was used to ascertain PEG incorporation and to analyze the change in the oxidation state of the polymer. Anodic cycling resulted in the formation of micrometer-sized surface cracks which increased the amount of Rhodamine-B dye adsorbed onto the surface, and played a role in decreasing the wettability of the surface. The change in surface wettability caused by these cracks was mitigated by the presence of PEG in the Ppy matrix. Compared to the incorporation of PEG, redox cycling was more effective in passively modulating the adhesion of NIH 3T3 fibroblast cells on the Ppy surface. Based on the attenuation of surface polarity of the Ppy surfaces by the incorporated PEG, a mechanism is proposed to explain the observed cell adhesion behavior.
AB - The surface properties of electrodeposited poly(pyrrole) (Ppy) doped with sodium dodecylbenzenesulphonate (NaDBS) are modified by two methods: addition of poly(ethylene glycol) (PEG) during the electrodeposition and through redox cycling post electrodeposition. X-ray photoelectron spectroscopy (XPS) was used to ascertain PEG incorporation and to analyze the change in the oxidation state of the polymer. Anodic cycling resulted in the formation of micrometer-sized surface cracks which increased the amount of Rhodamine-B dye adsorbed onto the surface, and played a role in decreasing the wettability of the surface. The change in surface wettability caused by these cracks was mitigated by the presence of PEG in the Ppy matrix. Compared to the incorporation of PEG, redox cycling was more effective in passively modulating the adhesion of NIH 3T3 fibroblast cells on the Ppy surface. Based on the attenuation of surface polarity of the Ppy surfaces by the incorporated PEG, a mechanism is proposed to explain the observed cell adhesion behavior.
KW - Cell adhesion
KW - Polyethylene glycol
KW - Polypyrrole
KW - Redox cycling
KW - X-ray photoelectron spectroscopy
UR - http://www.scopus.com/inward/record.url?scp=84879608674&partnerID=8YFLogxK
U2 - 10.1002/adhm.201200282
DO - 10.1002/adhm.201200282
M3 - Article
C2 - 23197463
AN - SCOPUS:84879608674
SN - 2192-2640
VL - 2
SP - 591
EP - 598
JO - Advanced Healthcare Materials
JF - Advanced Healthcare Materials
IS - 4
ER -