TY - JOUR
T1 - Red blood cells as carriers in magnetic particle imaging
AU - Antonelli, Antonella
AU - Sfara, Carla
AU - Rahmer, Jürgen
AU - Gleich, Bernhard
AU - Borgert, Jörn
AU - Magnani, Mauro
PY - 2013/12/1
Y1 - 2013/12/1
N2 - Red blood cells (RBCs) represent intravascular carriers for drugs, biologics, and other therapeutic agents, characterized by their unique longevity in the bloodstream, availability, considerable surface and volume, high biocompatibility, and natural mechanisms for safe elimination. Recently, the potential of RBCs loaded with superparamagnetic iron oxide (SPIO) nanoparticles as a tracer material for magnetic particle imaging (MPI) to realize a blood-pool tracer agent with longer blood retention time for imaging of the circulatory system, has been investigated. MPI is a new tomographic imaging approach that can quantitatively map magnetic nanoparticle distributions in vivo. However, SPIO contrast agents, such as Resovist, have a short blood half-life due to rapid uptake by the reticuloendothelial system, which limits the applicability of such compounds for certain applications such as long-term monitoring. Here, we report the in vitro magnetic characterization study of human SPIO-loaded RBCs and the first MPI results obtained after intravenous injection of murine SPIO-loaded RBCs in an in vivo MPI experiment.
AB - Red blood cells (RBCs) represent intravascular carriers for drugs, biologics, and other therapeutic agents, characterized by their unique longevity in the bloodstream, availability, considerable surface and volume, high biocompatibility, and natural mechanisms for safe elimination. Recently, the potential of RBCs loaded with superparamagnetic iron oxide (SPIO) nanoparticles as a tracer material for magnetic particle imaging (MPI) to realize a blood-pool tracer agent with longer blood retention time for imaging of the circulatory system, has been investigated. MPI is a new tomographic imaging approach that can quantitatively map magnetic nanoparticle distributions in vivo. However, SPIO contrast agents, such as Resovist, have a short blood half-life due to rapid uptake by the reticuloendothelial system, which limits the applicability of such compounds for certain applications such as long-term monitoring. Here, we report the in vitro magnetic characterization study of human SPIO-loaded RBCs and the first MPI results obtained after intravenous injection of murine SPIO-loaded RBCs in an in vivo MPI experiment.
KW - Carriers
KW - MPI
KW - SPIO nanoparticles
KW - red blood cells
UR - http://www.scopus.com/inward/record.url?scp=84890464491&partnerID=8YFLogxK
U2 - 10.1515/bmt-2012-0065
DO - 10.1515/bmt-2012-0065
M3 - Review article
C2 - 23839809
AN - SCOPUS:84890464491
SN - 0013-5585
VL - 58
SP - 517
EP - 525
JO - Biomedizinische Technik
JF - Biomedizinische Technik
IS - 6
ER -