Abstract
Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lost in ≥30% of human melanomas and was associated with reduced patient survival. These findings identify RASA2 inactivation as a melanoma driver and highlight the importance of RasGAPs in cancer.
Original language | English |
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Pages (from-to) | 1408-1410 |
Number of pages | 3 |
Journal | Nature Genetics |
Volume | 47 |
Issue number | 12 |
DOIs | |
State | Published - 1 Dec 2015 |
Externally published | Yes |