@article{36ce493608634649bc35863cb27d3447,
title = "Recognition of RNA virus by RIG-I results in activation of CARD9 and inflammasome signaling for interleukin 1Β production",
abstract = "Interleukin 1Β (IL-1Β) is a potent proinflammatory factor during viral infection. Its production is tightly controlled by transcription of Il1b dependent on the transcription factor NF-B and subsequent processing of pro-IL-1Β by an inflammasome. However, the sensors and mechanisms that facilitate RNA virus-induced production of IL-1Β are not well defined. Here we report a dual role for the RNA helicase RIG-I in RNA virus-induced proinflammatory responses. Whereas RIG-I-mediated activation of NF-B required the signaling adaptor MAVS and a complex of the adaptors CARD9 and Bcl-10, RIG-I also bound to the adaptor ASC to trigger caspase-1-dependent inflammasome activation by a mechanism independent of MAVS, CARD9 and the Nod-like receptor protein NLRP3. Our results identify the CARD9-Bcl-10 module as an essential component of the RIG-I-dependent proinflammatory response and establish RIG-I as a sensor able to activate the inflammasome in response to certain RNA viruses.",
author = "Hendrik Poeck and Michael Bscheider and Olaf Gross and Katrin Finger and Susanne Roth and Manuele Rebsamen and Nicole Hannesschl{\"a}ger and Martin Schlee and Simon Rothenfusser and Winfried Barchet and Hiroki Kato and Shizuo Akira and Satoshi Inoue and Stefan Endres and Christian Peschel and Gunther Hartmann and Veit Hornung and J{\"u}rgen Ruland",
note = "Funding Information: We thank J. Tschopp (University of Lausanne) for critical reading of the manuscript, discussions and NLRP3-deficient, ASC-deficient and MAVS-deficient mice and plasmids; and A. Krug (Technical University of Munich) for EMCV. This work includes parts of a thesis by M.B. at the University of Munich. Supported by Bundesministerium f{\"u}r Bildung und Forschung Biofuture (G.H.), Deutsche Forschungsgemeinschaft (SFB704, SFB670, SFB832 and KFO177 to G.H.; Sonderforschungsbereiche to S.E., V.H. and J.R.; Graduiertenkolleg 1202 to M.B.; and RO 2525/3–1 to S.R.), the Center for Integrated Protein Science Munich (S.E.), the European Research Council (V.H.) and Deutsche Krebshilfe (J.R.).",
year = "2010",
month = jan,
doi = "10.1038/ni.1824",
language = "English",
volume = "11",
pages = "63--69",
journal = "Nature Immunology",
issn = "1529-2908",
publisher = "Nature Research",
number = "1",
}