Recent developments and aspects of industrial fluoroalkylation

Matthias Beller, Florian Fischer, Andreas Locher, Helfried Neumann, Christoph Taeschler, Fei Ye, Shaoke Zhang

Research output: Contribution to journalArticlepeer-review

2 Scopus citations

Abstract

Fluoroalkylations have received increasing attention in the academic and industrial environment due to the particular properties of the active ingredients that are strongly influenced by fluoroalkyl substituents. The inherent difficulties of introducing a fluoroalkyl substituent into advanced intermediates has triggered the development of an enormous number of specialized reagents, which, however, are often not suitable for large scale applications. In contrast to this reagent based fluoroalkylation approach, the direct activation of industrially readily available fluoroalkyl halides could be more suitable for a large-scale process. In this way the dithionite initiated fluoroalkylation as well as newly developed catalytically activated fluoroalkylation protocols were considered for industrial large-scale applications.

Original languageEnglish
Pages (from-to)923-935
Number of pages13
JournalChimia
Volume75
Issue number11
DOIs
StatePublished - Nov 2021
Externally publishedYes

Keywords

  • Catalysis
  • Dithionite
  • Fluoroalkylation
  • Industry
  • Sulfinatodehalogenation

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