Recent advances in research on hepadnaviral infection in the woodchuck model

Ina Schulte; E. Juan Zhang; Zhong Ji Meng; Rong Juan Pei; Mengji Lu; Michael Roggendorf

doi:10.1007/s12250-008-2941-z

Recent advances in research on hepadnaviral infection in the woodchuck model

Ina Schulte, E. Juan Zhang, Zhong Ji Meng, Rong Juan Pei, Mengji Lu, Michael Roggendorf

Research output: Contribution to journal › Article › peer-review

1 Scopus citations

Abstract

The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

Original language	English
Pages (from-to)	107-115
Number of pages	9
Journal	Virologica Sinica
Volume	23
Issue number	2
DOIs	https://doi.org/10.1007/s12250-008-2941-z
State	Published - 2008
Externally published	Yes

Keywords

Chronic hepatitis B
Hepatitis B virus (HBV)
Woodchuck hepatitis virus (WHV)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s12250-008-2941-z

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title = "Recent advances in research on hepadnaviral infection in the woodchuck model",

abstract = "The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.",

keywords = "Chronic hepatitis B, Hepatitis B virus (HBV), Woodchuck hepatitis virus (WHV)",

author = "Ina Schulte and Zhang, {E. Juan} and Meng, {Zhong Ji} and Pei, {Rong Juan} and Mengji Lu and Michael Roggendorf",

note = "Funding Information: This work is supported by Deutsche Forschungs-gemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/ 5-1).",

year = "2008",

doi = "10.1007/s12250-008-2941-z",

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journal = "Virologica Sinica",

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T1 - Recent advances in research on hepadnaviral infection in the woodchuck model

AU - Schulte, Ina

AU - Zhang, E. Juan

AU - Meng, Zhong Ji

AU - Pei, Rong Juan

AU - Lu, Mengji

AU - Roggendorf, Michael

N1 - Funding Information: This work is supported by Deutsche Forschungs-gemeinschaft (Lu 669/2-1, GRK1045/1, and Lu 669/ 5-1).

PY - 2008

Y1 - 2008

N2 - The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

AB - The woodchuck model is an excellent animal model to study hepadnaviral infection. The new progresses in this model made possible to examine the T-cell mediated immune responses in acute and chronic hepadnaviral infection. Recently, a new assay for cytotoxic T-cells based on detection of CD107 was established for the woodchuck model. In addition, new immunotherapeutic approaches based on combination of potent antiviral treatment and DNA-protein vaccines were proven to be useful for treatment of chronic hepatitis B.

KW - Chronic hepatitis B

KW - Hepatitis B virus (HBV)

KW - Woodchuck hepatitis virus (WHV)

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JO - Virologica Sinica

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ER -

Recent advances in research on hepadnaviral infection in the woodchuck model

Abstract

Keywords

UN SDGs

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