TY - JOUR
T1 - Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution
AU - Estrada, Héctor
AU - Turner, Jake
AU - Kneipp, Moritz
AU - Razansky, Daniel
PY - 2014/4
Y1 - 2014/4
N2 - Conventional optoacoustic microscopy operates in two distinct modes of optical resolution, for visualization of superficial tissue layers, or acoustic resolution, intended for deep imaging in scattering tissues. Here we introduce a new microscope design with hybrid optical and acoustic resolution, which provides a smooth transition from optical resolution in superficial microscopic imaging to ultrasonic resolution when imaging at greater depths within intensely scattering tissue layers. Experimental validation of the new hybrid optoacoustic microscopy method was performed in phantoms and by means of transcranial mouse brain imaging in vivo.
AB - Conventional optoacoustic microscopy operates in two distinct modes of optical resolution, for visualization of superficial tissue layers, or acoustic resolution, intended for deep imaging in scattering tissues. Here we introduce a new microscope design with hybrid optical and acoustic resolution, which provides a smooth transition from optical resolution in superficial microscopic imaging to ultrasonic resolution when imaging at greater depths within intensely scattering tissue layers. Experimental validation of the new hybrid optoacoustic microscopy method was performed in phantoms and by means of transcranial mouse brain imaging in vivo.
KW - in vivo imaging
KW - optoacoustic imaging
KW - optoacoustic microscopy
KW - transcranial imaging, hybrid focusing
UR - http://www.scopus.com/inward/record.url?scp=84896518523&partnerID=8YFLogxK
U2 - 10.1088/1612-2011/11/4/045601
DO - 10.1088/1612-2011/11/4/045601
M3 - Article
AN - SCOPUS:84896518523
SN - 1612-2011
VL - 11
JO - Laser Physics Letters
JF - Laser Physics Letters
IS - 4
M1 - 045601
ER -