Real-time optoacoustic brain microscopy with hybrid optical and acoustic resolution

Héctor Estrada, Jake Turner, Moritz Kneipp, Daniel Razansky

Research output: Contribution to journalArticlepeer-review

76 Scopus citations


Conventional optoacoustic microscopy operates in two distinct modes of optical resolution, for visualization of superficial tissue layers, or acoustic resolution, intended for deep imaging in scattering tissues. Here we introduce a new microscope design with hybrid optical and acoustic resolution, which provides a smooth transition from optical resolution in superficial microscopic imaging to ultrasonic resolution when imaging at greater depths within intensely scattering tissue layers. Experimental validation of the new hybrid optoacoustic microscopy method was performed in phantoms and by means of transcranial mouse brain imaging in vivo.

Original languageEnglish
Article number045601
JournalLaser Physics Letters
Issue number4
StatePublished - Apr 2014


  • in vivo imaging
  • optoacoustic imaging
  • optoacoustic microscopy
  • transcranial imaging, hybrid focusing


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