Reactogenicity of tetanus, diphtheria, 5-component acellular pertussis vaccine administered as a sixth consecutive acellular pertussis vaccine dose to adolescents

Johannes G. Liese, Nikolaus Rieber, Thomas Malzer, Marion Ocak, David R. Johnson, Michael D. Decker

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Background: Safety of a sixth consecutive dose of acellular pertussis vaccine in adolescents was assessed in a 2-armed, randomized study. Methods: Adolescents who had received 5 doses of acellular pertussis vaccine combined with diphtheria and tetanus toxoids (6-dose group) received 1 dose of reduced 5-component acellular pertussis vaccine combined with tetanus toxoid and reduced diphtheria toxoid (Tdap). Adolescents who had received a primary series of 3 doses of whole-cell pertussis and 1 acellular or whole-cell pertussis booster received 1 dose of Tdap vaccine (5-dose group). Results: Of 214 participants, 176 (82%) reported an injection-site reaction with pain (80%), erythema (22%), and swelling (19%) most frequently reported. A systemic reaction was reported by 169 of 214 (79%) with myalgia (66%), headache (42%), malaise (39%), and fever (9%) most frequently reported. The overall rate of solicited reactions was lower in the 6-dose group than in the 5-dose group (for injection-site reactions: 76.1% vs. 89.7%; for systemic reactions 72.6% vs. 86.6%). Significant differences were observed for injection-site pain, erythema, and for grade 1 or grade 2 increases in arm circumference. Fever, myalgia, and headache were reported at a significantly lower rate in the 6-dose group. Swelling >10 cm was observed in 5 patients (2%), 4 in the 5-dose group. Conclusions: Tdap vaccine was safe when given to adolescents who had received 5 prior doses of acellular pertussis vaccine.

Original languageEnglish
Pages (from-to)1067-1071
Number of pages5
JournalPediatric Infectious Disease Journal
Volume29
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • acellular pertussis vaccine
  • adolescents
  • reactogenicity
  • Tdap

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