Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

Thomas Kietzmann; Agnes Görlach

doi:10.1016/j.semcdb.2005.03.010

Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

Thomas Kietzmann, Agnes Görlach

Associate Professorship of Cardiovascular Biology

University of Kaiserslautern

Research output: Contribution to journal › Review article › peer-review

257 Scopus citations

Abstract

Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.

Original language	English
Pages (from-to)	474-486
Number of pages	13
Journal	Seminars in Cell and Developmental Biology
Volume	16
Issue number	4-5
DOIs	https://doi.org/10.1016/j.semcdb.2005.03.010
State	Published - 2005

Keywords

HIF
Hypoxia
NADPH oxidase
Oxygen sensing
Reactive oxygen species

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10.1016/j.semcdb.2005.03.010

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title = "Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression",

abstract = "Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.",

keywords = "HIF, Hypoxia, NADPH oxidase, Oxygen sensing, Reactive oxygen species",

author = "Thomas Kietzmann and Agnes G{\"o}rlach",

note = "Funding Information: Work in the authors{\textquoteright} laboratories is supported by the Deutsche Forschungsgemeinschaft grants GO 709/4-1 and GRK438 and by the sixth framework programme of the European Commission (EUROXY) to AG and by Deutsche Forschungsgemeinschaft grants SFB 402 Teilprojekt A1 and GRK 335, Deutsche Krebshilfe 106429 and grants from Fonds der Chemischen Industrie to TK.",

year = "2005",

doi = "10.1016/j.semcdb.2005.03.010",

language = "English",

volume = "16",

pages = "474--486",

journal = "Seminars in Cell and Developmental Biology",

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TY - JOUR

T1 - Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

AU - Kietzmann, Thomas

AU - Görlach, Agnes

N1 - Funding Information: Work in the authors’ laboratories is supported by the Deutsche Forschungsgemeinschaft grants GO 709/4-1 and GRK438 and by the sixth framework programme of the European Commission (EUROXY) to AG and by Deutsche Forschungsgemeinschaft grants SFB 402 Teilprojekt A1 and GRK 335, Deutsche Krebshilfe 106429 and grants from Fonds der Chemischen Industrie to TK.

PY - 2005

Y1 - 2005

N2 - Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.

AB - Reactive oxygen species (ROS) have long been considered as cytotoxic. However, recent evidence indicates a prominent role of ROS as signaling molecules in the response to hormones, growth and coagulation factors, cytokines and other factors as well as to changes in oxygen tension. The hypoxia-inducible transcription factors (HIFs) are key players in the cellular response to changes in oxygen tension. Recently, HIFs have also been shown to respond to the above-mentioned non-hypoxic stimuli. In this article, the role of ROS in the regulation of HIF-1 under hypoxic and non-hypoxic conditions is summarized.

KW - HIF

KW - Hypoxia

KW - NADPH oxidase

KW - Oxygen sensing

KW - Reactive oxygen species

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U2 - 10.1016/j.semcdb.2005.03.010

DO - 10.1016/j.semcdb.2005.03.010

M3 - Review article

C2 - 15905109

AN - SCOPUS:24344438196

SN - 1084-9521

VL - 16

SP - 474

EP - 486

JO - Seminars in Cell and Developmental Biology

JF - Seminars in Cell and Developmental Biology

IS - 4-5

ER -

Reactive oxygen species in the control of hypoxia-inducible factor-mediated gene expression

Abstract

Keywords

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