Abstract
One life, two strategies: Crucial structural differences between the human and the Plasmodium falciparum proteasomes were recently identified. A combination of cryo-EM and functional characterization enabled the design of a selective antimalarial proteasome inhibitor that shows low toxicity in the host. When used with artemisinin, this ligand offers a new approach for the efficient treatment of malaria at all stages of the parasite lifecycle.
| Original language | English |
|---|---|
| Pages (from-to) | 6370-6372 |
| Number of pages | 3 |
| Journal | Angewandte Chemie International Edition in English |
| Volume | 55 |
| Issue number | 22 |
| DOIs | |
| State | Published - 23 May 2016 |
Keywords
- cryo-electron microscopy
- drug design
- malaria
- proteasome
- structure-activity relationship
