Rat liver microsomal transformation of ethene to oxirane in vitro

G. Schmiedel; J. G. Filser; H. M. Bolt

doi:10.1016/0378-4274(83)90133-9

Rat liver microsomal transformation of ethene to oxirane in vitro

G. Schmiedel, J. G. Filser, H. M. Bolt

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Abstract

Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

Original language	English
Pages (from-to)	293-297
Number of pages	5
Journal	Toxicology Letters
Volume	19
Issue number	3
DOIs	https://doi.org/10.1016/0378-4274(83)90133-9
State	Published - Dec 1983
Externally published	Yes

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title = "Rat liver microsomal transformation of ethene to oxirane in vitro",

abstract = "Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.",

author = "G. Schmiedel and Filser, {J. G.} and Bolt, {H. M.}",

year = "1983",

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doi = "10.1016/0378-4274(83)90133-9",

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AU - Schmiedel, G.

AU - Filser, J. G.

AU - Bolt, H. M.

PY - 1983/12

Y1 - 1983/12

N2 - Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

AB - Rat liver microsomal monooxygenases transform ethene to oxirane. Compared with 1,3-butadiene, which is metabolized to vinyl oxirane, this transformation proceeds more slowly. Also, oxirane has a distinctly lower alkylating potency than vinyloxirane towards the test reagent (p-nitrobenzyl)-pyridine. This may suggest a lower toxicity of ethene, compared with butadiene.

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DO - 10.1016/0378-4274(83)90133-9

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VL - 19

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JO - Toxicology Letters

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ER -

Rat liver microsomal transformation of ethene to oxirane in vitro

Abstract

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