RamB is an activator of the pyruvate dehydrogenase complex subunit E1p gene in Corynebacterium glutamicum

Bastian Blombach, Annette Cramer, Bernhard J. Eikmanns, Mark Schreiner

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

In Corynebacterium glutamicum, the transcriptional regulator RamB negatively controls the expression of genes involved in acetate metabolism. Here we show that during growth in media containing glucose and in complex medium without glucose RamB activates expression of the aceE gene, encoding the E1p subunit of the pyruvate dehydrogenase complex. Thus, RamB functions both as repressor and as activator in C. glutamicum.

Original languageEnglish
Pages (from-to)236-239
Number of pages4
JournalJournal of Molecular Microbiology and Biotechnology
Volume16
Issue number3-4
DOIs
StatePublished - Feb 2009
Externally publishedYes

Keywords

  • Acetate metabolism
  • Corynebacterium glutamicum
  • Pyruvate dehydrogenase complex
  • RamB
  • Transcriptional regulation

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