Radiochemical 18F-fluoroarylation of unsaturated α-, β- and γ-amino acids, application to a radiolabelled analogue of baclofen

Sarah B. Höfling, Christina Hultsch, Hans Jürgen Wester, Markus R. Heinrich

Research output: Contribution to journalArticlepeer-review

12 Scopus citations

Abstract

Unsaturated α-, β- and γ-amino acids have been investigated as substrates for the reductive Meerwein arylation. Radical reactions of this type have been shown to be a valuable tool for the fast and efficient introduction of the 4-[18F]fluorophenyl group into precursor molecules allowing short-time syntheses of potential PET radiotracers, which would be more difficult to access by other methods.

Original languageEnglish
Pages (from-to)11846-11851
Number of pages6
JournalTetrahedron
Volume64
Issue number52
DOIs
StatePublished - 22 Dec 2008

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