Radical fluoroarylation in radiochemical synthesis

Christina Hultsch, Olga Blank, Hans Jürgen Wester, Markus R. Heinrich

Research output: Contribution to journalArticlepeer-review

10 Scopus citations

Abstract

In this study, we report on the radical [18F]fluoroarylation of different olefins using 4-[18F]fluorobenzenediazonium ions to provide a new route to radiopharmaceuticals containing a deactivated, 4-[18F]fluoro substituted phenyl group. This new methodology was shown to be well suited for the synthesis of 18F-labelled stilbenes. Stilbene 7 is now accessible within 80 min in 30-45% overall radiochemical yield starting from [18F]fluoride.

Original languageEnglish
Pages (from-to)1881-1883
Number of pages3
JournalTetrahedron Letters
Volume49
Issue number11
DOIs
StatePublished - 10 Mar 2008
Externally publishedYes

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