Radiation-induced meningeal and pituitary tumors in the rat after prenatal application of strontium-90

W. schmahl, W. E. Kollmer

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11 Scopus citations


Strontium-90 was injected i. v. into pregnant rats on day 18 post conception (p. c.). This caused a remarkable transplacental radioactivity uptake and accumulation in the ossification centers of the skull basis. The total radiation dose within the surface of these regions was consequently calculated to be 0.6-1.2 Gy within the entire lifespan. About 50% of it was delivered during the 7 days following the injection of the isotope. the pathologic examination of the offspring throughout their lifetime revealed a pituitary tumor frequency in the exposed groups which was about tenfold in the males and threefold in the females in comparison to the controls. A very outstanding result in the animals treated was the occurrence of metastasizing meningeal sarcomas in about 6% of all cases. In four cases (=2%) the simultaneous occurrence of a pituitary adenoma and of a meningeal sarcoma could be observed.

Original languageEnglish
Pages (from-to)13-18
Number of pages6
JournalJournal of Cancer Research and Clinical Oncology
Issue number1
StatePublished - Apr 1981
Externally publishedYes


  • Head
  • In utero
  • Rat
  • Strontium 90
  • Tumors


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