Quantitative three-dimensional imaging of lipid, protein, and water contents via x-ray phase-contrast tomography

Marian Willner, Manuel Viermetz, Mathias Marschner, Kai Scherer, Christian Braun, Alexander Fingerle, Peter Noël, Ernst Rummeny, Franz Pfeiffer, Julia Herzen

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

X-ray phase-contrast computed tomography is an emerging imaging technology with powerful capabilities for three-dimensional (3D) visualization of weakly absorbing objects such as biological soft tissues. This technique is an extension of existing X-ray applications because conventional attenuation-contrast images are simultaneously acquired. The complementary information provided by both the contrast modalities suggests that enhanced material characterization is possible when performing combined data analysis. In this study, we describe how protein, lipid, and water concentrations in each 3D voxel can be quantified by vector decomposition. Experimental results of dairy products, porcine fat and rind, and different human soft tissue types are presented. The results demonstrate the potential of phase-contrast imaging as a new analysis tool. The 3D representations of protein, lipid, and water contents open up new opportunities in the fields of biology, medicine, and food science.

Original languageEnglish
Article numbere0151889
JournalPLoS ONE
Volume11
Issue number3
DOIs
StatePublished - Mar 2016

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