Quantitative CT scan analysis in senile dementia of the Alzheimer type: I. Computerized planimetry of cerebrospinal fluid areas

Hans Förstl, Alistair Burns, Robin Jacoby, Sarah Eagger, Raymond Levy

Research output: Contribution to journalArticlepeer-review

11 Scopus citations

Abstract

Sixty patients with senile dementia of the Alzheimer type (DAT) and 30 age and sex‐matched healthy controls were examined by cranial computed tomography (CT). We undertook this study to evaluate a simple and unbiased quantitative method for the estimation of ventricular and subarachnoid spaces by measuring areas of defined Hounsfield units (HUs) in four symmetric quadrants: left and right anterior, left and right posterior. The DAT patients showed a significant enlargement of all ventricles and all measured subarachnoid spaces (p< 0.001). These effects were not related to the age but to the diagnosis. They correlated with the duration of disease and partly with the degree of global cognitive impairment. Seventy‐eight per cent of the patients and controls could be classified correctly by means of the planimetric measurements.

Original languageEnglish
Pages (from-to)709-713
Number of pages5
JournalInternational Journal of Geriatric Psychiatry
Volume6
Issue number10
DOIs
StatePublished - Oct 1991
Externally publishedYes

Keywords

  • Computed tomography
  • dementia
  • planimetry
  • senile dementia of the Alzheimer type

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