TY - JOUR
T1 - Quantifying progression in primary progressive aphasia with structural neuroimaging
AU - the FTLD consortium
AU - Lombardi, Jolina
AU - Mayer, Benjamin
AU - Semler, Elisa
AU - Anderl-Straub, Sarah
AU - Uttner, Ingo
AU - Kassubek, Jan
AU - Diehl-Schmid, Janine
AU - Danek, Adrian
AU - Levin, Johannes
AU - Fassbender, Klaus
AU - Fliessbach, Klaus
AU - Schneider, Anja
AU - Huppertz, Hans Jürgen
AU - Jahn, Holger
AU - Volk, Alexander
AU - Kornhuber, Johannes
AU - Landwehrmeyer, Bernhard
AU - Lauer, Martin
AU - Prudlo, Johannes
AU - Wiltfang, Jens
AU - Schroeter, Matthias L.
AU - Ludolph, Albert
AU - Otto, Markus
AU - von Arnim, Christine
AU - Steinacker, Petra
AU - Müller, Hans Peter
AU - Oberhauser, Felix
AU - Schumacher, Kai
AU - Lehmbeck, Jan
AU - Maler, Juan Manuel
AU - Richter-Schmidinger, Tanja
AU - Hammer-Kaspereit, Anke
AU - Oberstein, Timo
AU - Pino, Daniele
AU - Polyakova, Maryna
AU - Hüper, Lea
AU - Regenbrecht, Frank
AU - Thöne-Otto, Angelika
AU - Müller-Sarnowski, Felix
AU - Roßmeier, Carola
N1 - Publisher Copyright:
© 2021 The Authors. Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.
PY - 2021/10
Y1 - 2021/10
N2 - Introduction: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods: Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results: At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.
AB - Introduction: The term primary progressive aphasia (PPA) sums up the non-fluent (nfv), the semantic (sv), and the logopenic (lv) variant. Up to now, there is only limited data available concerning magnetic resonance imaging volumetry to monitor disease progression. Methods: Structural brain imaging and an extensive assessment were applied at baseline and up to 4-year(s) follow-up in 269 participants. With automated atlas-based volumetry 56 brain regions were assessed. Atrophy progression served to calculate sample sizes for therapeutic trials. Results: At baseline highest atrophy appeared in parts of the left frontal lobe for nfvPPA (–17%) and of the left temporal lobe for svPPA (–34%) and lvPPA (–24%). Severest progression within 1-year follow-up occurred in the basal ganglia in nfvPPA (–7%), in the hippocampus/amygdala in svPPA (–9%), and in (medial) temporal regions in lvPPA (–6%). Conclusion: PPA presents as a left-dominant, mostly gray matter sensitive disease with considerable atrophy at baseline that proceeds variant-specific.
KW - atlas-based volumetry
KW - disease progression
KW - frontotemporal dementia
KW - longitudinal magnetic resonance imaging
KW - primary progressive aphasia
KW - sample size calculation
UR - http://www.scopus.com/inward/record.url?scp=85103588892&partnerID=8YFLogxK
U2 - 10.1002/alz.12323
DO - 10.1002/alz.12323
M3 - Article
C2 - 33787063
AN - SCOPUS:85103588892
SN - 1552-5260
VL - 17
SP - 1595
EP - 1609
JO - Alzheimer's and Dementia
JF - Alzheimer's and Dementia
IS - 10
ER -
