Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP 31P-MR-spektroskopie

Meinrad Beer; W. Landschütz; M. Meininger; T. Seyfarth; M. Viehrig; J. Sandstede; T. Pabst; W. Kenn; M. Horn; K. Harre; M. Von Kienlin; S. Neubauer; D. Hahn

Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP ³¹P-MR-spektroskopie

Translated title of the contribution: Determination of absolute concentrations of cardiac highenergy phosphates using ³¹P-MR-spectroscopy and SLOOP in healthy and diseased myocardium

Meinrad Beer, W. Landschütz, M. Meininger, T. Seyfarth, M. Viehrig, J. Sandstede, T. Pabst, W. Kenn, M. Horn, K. Harre, M. Von Kienlin, S. Neubauer, D. Hahn

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University of Würzburg

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16 Scopus citations

Abstract

Purpose: A quantitative ³¹P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium. Methods: ³¹P-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by ¹H- images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: ³¹P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: ³¹P-MR- spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.

Translated title of the contribution	Determination of absolute concentrations of cardiac highenergy phosphates using ³¹P-MR-spectroscopy and SLOOP in healthy and diseased myocardium
Original language	German
Pages (from-to)	65-68
Number of pages	4
Journal	RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren
Volume	171
Issue number	1
State	Published - Jul 1999

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Beer, M., Landschütz, W., Meininger, M., Seyfarth, T., Viehrig, M., Sandstede, J., Pabst, T., Kenn, W., Horn, M., Harre, K., Von Kienlin, M., Neubauer, S., & Hahn, D. (1999). Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP ³¹P-MR-spektroskopie. RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, 171(1), 65-68.

@article{01337dff39114b0fb83916be46226c44,

title = "Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP 31P-MR-spektroskopie",

abstract = "Purpose: A quantitative 31P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium. Methods: 31P-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by 1H- images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: 31P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: 31P-MR- spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.",

keywords = "High energy phosphate, Nuclear magnetic resonance, Quantitative measurements, Spectroscopy",

author = "Meinrad Beer and W. Landsch{\"u}tz and M. Meininger and T. Seyfarth and M. Viehrig and J. Sandstede and T. Pabst and W. Kenn and M. Horn and K. Harre and {Von Kienlin}, M. and S. Neubauer and D. Hahn",

year = "1999",

month = jul,

language = "Deutsch",

volume = "171",

pages = "65--68",

journal = "RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren",

issn = "0936-6652",

publisher = "Georg Thieme Verlag",

number = "1",

}

Beer, M, Landschütz, W, Meininger, M, Seyfarth, T, Viehrig, M, Sandstede, J, Pabst, T, Kenn, W, Horn, M, Harre, K, Von Kienlin, M, Neubauer, S & Hahn, D 1999, 'Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP ³¹P-MR-spektroskopie', RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, vol. 171, no. 1, pp. 65-68.

Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP ³¹P-MR-spektroskopie. / Beer, Meinrad; Landschütz, W.; Meininger, M. et al.
In: RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren, Vol. 171, No. 1, 07.1999, p. 65-68.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP 31P-MR-spektroskopie

AU - Beer, Meinrad

AU - Landschütz, W.

AU - Meininger, M.

AU - Seyfarth, T.

AU - Viehrig, M.

AU - Sandstede, J.

AU - Pabst, T.

AU - Kenn, W.

AU - Horn, M.

AU - Harre, K.

AU - Von Kienlin, M.

AU - Neubauer, S.

AU - Hahn, D.

PY - 1999/7

Y1 - 1999/7

N2 - Purpose: A quantitative 31P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium. Methods: 31P-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by 1H- images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: 31P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: 31P-MR- spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.

AB - Purpose: A quantitative 31P-MR-spectroscopic technique was used to assess the energy metabolism in healthy and diseased myocardium. Methods: 31P-spectra were acquired on a 1.5 T scanner using a 3D-chemical shift imaging technique. Based on the anatomical information provided by 1H- images, SLOOP (Spatial Localization with Optimal Pointspread Function) allows to obtain spectra from defined compartments. With SLOOP a free voxel shape with adaption to anatomic structures, e.g. the myocardium, is possible. Absolute values for phosphocreatine (PCr) and adenosine triphosphate (ATP) were determined using an external standard. Results: 31P-spectra showed only minimal contamination by surrounding tissue. The standard deviation for the determined values of healthy volunteers was low. Compared to healthy volunteers, reduced PCr and ATP concentrations were seen for dilative cardiomyopathies and coronary artery disease and unchanged concentrations were observed for hypertensive heart disease. Conclusion: 31P-MR- spectroscopy with SLOOP allows a non-invasive, quantitative analysis of cardiac energy metabolism.

KW - High energy phosphate

KW - Nuclear magnetic resonance

KW - Quantitative measurements

KW - Spectroscopy

UR - http://www.scopus.com/inward/record.url?scp=0032730467&partnerID=8YFLogxK

M3 - Artikel

C2 - 10464508

AN - SCOPUS:0032730467

SN - 0936-6652

VL - 171

SP - 65

EP - 68

JO - RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren

JF - RoFo Fortschritte auf dem Gebiete der Rontgenstrahlen und der Neuen Bildgebenden Verfahren

IS - 1

ER -

Quantifizierung energiereicher phosphate im gesunden und geschadigten herzmuskel mittels SLOOP ³¹P-MR-spektroskopie

Abstract

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