TY - JOUR
T1 - Pulmonary metastasectomy following chemotherapy in patients with testicular tumors
T2 - Experience in 52 patients
AU - Pfannschmidt, J.
AU - Zabeck, H.
AU - Muley, T.
AU - Dienemann, H.
AU - Hoffmann, H.
PY - 2006/10
Y1 - 2006/10
N2 - Background: Surgical resection is an important form of treatment for residual post-chemotherapy pulmonary masses in patients with non-seminomatous germ cell tumors. We analyzed the outcome and prognostic factors after surgery. Methods: Between 1996 and 2001, 52 patients underwent pulmonary resection of thoracic masses following cisplatin-based chemotherapy. These patients' records were subsequently reviewed. Results: The overall 5-year survival rate was 75.8%. A significantly longer survival was observed using multivariate analysis in patients with normal serum AFP and/or hCG tumor marker levels and after complete surgical resection. In patients with viable malignant tumor cells in the resected specimen and in patients with only necrosis/fibrosis or teratoma, the 5-year survival rates were 49.6% and 82.8%, respectively. This difference was only statistically significant in univariate analysis. Conclusions: We conclude that pulmonary resection in metastatic non-seminomatous germ cell tumors is a safe and effective treatment modality. Incomplete resection and elevated tumor marker levels, AFP and/or hCG, were identified as prognosis-related criteria for a poor outcome in multivariate analysis.
AB - Background: Surgical resection is an important form of treatment for residual post-chemotherapy pulmonary masses in patients with non-seminomatous germ cell tumors. We analyzed the outcome and prognostic factors after surgery. Methods: Between 1996 and 2001, 52 patients underwent pulmonary resection of thoracic masses following cisplatin-based chemotherapy. These patients' records were subsequently reviewed. Results: The overall 5-year survival rate was 75.8%. A significantly longer survival was observed using multivariate analysis in patients with normal serum AFP and/or hCG tumor marker levels and after complete surgical resection. In patients with viable malignant tumor cells in the resected specimen and in patients with only necrosis/fibrosis or teratoma, the 5-year survival rates were 49.6% and 82.8%, respectively. This difference was only statistically significant in univariate analysis. Conclusions: We conclude that pulmonary resection in metastatic non-seminomatous germ cell tumors is a safe and effective treatment modality. Incomplete resection and elevated tumor marker levels, AFP and/or hCG, were identified as prognosis-related criteria for a poor outcome in multivariate analysis.
KW - Non-seminomatous testicular germ cell tumor
KW - Prognostic factor
KW - Thoracic surgery
UR - http://www.scopus.com/inward/record.url?scp=33750601820&partnerID=8YFLogxK
U2 - 10.1055/s-2006-924246
DO - 10.1055/s-2006-924246
M3 - Article
C2 - 17089317
AN - SCOPUS:33750601820
SN - 0171-6425
VL - 54
SP - 484
EP - 488
JO - Thoracic and Cardiovascular Surgeon
JF - Thoracic and Cardiovascular Surgeon
IS - 7
ER -